STOCKHOLM, June 22, 2020 /PRNewswire/ -- Cantargia AB ("Cantargia") today presented new preclinical data giving additional knowledge around the mechanisms and thereby relevance of adding the

Cantargia Presents New Preclinical Data on CAN04 at the 2020 AACR Annual Meeting. PRESS RELEASE PR Newswire . Jun. 22, 2020, 03:13 PM

Antibody-Dependent Cellular Cytotoxicity (ADCC) samt blockad av interleukin-1 signalering. CAN04 studeras för närvarande i en öppen trearmad fas I/IIa klinisk prövning, CANFOUR. About CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1α and IL-1β signaling. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Här undersöks CAN04 både som monoterapi liksom i kombinationsterapi med två olika cellgiftsregimer i patienter med icke-småcellig lungcancer eller bukspottskörtelcancer (www.clinicaltrials.gov).

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Cantargias ledande projekt, antikroppen CAN04, uppfyller kraven för att Bristen på effektiva preparat mot PDAC skulle vid positiv fas 2a-data 

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Cantargia AB, a biotechnology company, announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 per cent of patients with bladder cancer.

The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 increases the efficacy of chemotherapy. Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab). Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented at the ESMO Congress 2018 in Munich, Germany. CAN04 is in clinical development for cancer therapy and targets interleukin 1 receptor accessory protein, IL1RAP, positive single agent clinical data was recently presented at ESMO.

Novartis reported negative data from its Phase III CANOPY-2 trial for canakinumab in 2nd/3rd-line NSCLC; canakinumab targets the same IL-1 pathway as CAN04, but in a more restricted way. This has triggered negative sentiment towards Cantargia’s share price. However, we note that the readout coincided with the ongoing correction in the European and US biotechnology subsectors as well as in Kort därefter räknar bolaget med att starta studier med Can04 i ett flertal andra cancersjukdomar. "Den här så kallade korgstudien är inte färdigdesignad, men vi räknar med att kunna informera mer kring den under våren", skriver Göran Forsberg. I Can10-projektet planerar Cantargia kliniska studier i början på nästa år. Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda. Cantargia AB: Cantargia presents new preclinical data on CAN04 in combination with chemotherapy at the 2020 AACR Annual Meeting.
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Cantargia rapporterar positiva interimsdata från pågående fas IIa-kombinationsstudien med antikroppen CAN04. mån, dec 02, 2019 10:30 CET. CAN04 is investigated in an open label three-armed phase I/IIa clinical trial, CANFOUR, examining monotherapy as well as combination with two  Preclinical data show that CAN04 can increase the efficacy of chemotherapy.

reported data from 1 patient in the Phase I/IIa CANFOUR trial showing that once-weekly IV CAN04..adverse events. The first part of the open-label, European trial is evaluating escalating doses of CAN04..pancreatic cancer, colorectal cancer or triple-negative breast cancer (TNBC), and the second part will evaluate CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP).
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Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab). Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented at the ESMO Congress 2018 in Munich, Germany.

Azadirachtin - P-711S 100 µg/mL in Methanol - 1 comp |  Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting.

Preclinical data show that CAN04 increases the efficacy of chemotherapy. CAN04 is investigated in a phase I/IIa clinical trial, CANFOUR, 

Nya fas I kliniska data på antikroppen CAN04 (nidanilimab) presenterades idag som en muntlig presentation på konferensen "2019 ASCO Annual Meeting". Data från 22 patienter visar att CAN04-behandling är förenat med god säkerhet.

Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy. CAN04 is investigated in two clinical trials. The data show that by adding CAN04, response rates are higher than historical data using these standard first line chemotherapies alone. 4 out of 7 evaluable patients with metastatic pancreatic cancer (PDAC) and 2 out of 3 patients with metastatic non-small cell lung cancer (NSCLC), including 1 patient with complete response (CR), had objective responses. 2019-08-23 · Cantargia har meddelat nya positiva prekliniska data för bolagets antikropp CAN04. Målmolekylen för CAN04, IL1RAP, har påvisats på cancercellerna hos cirka 80 procent patienterna med urinblåsecancer. CAN04 prissätts till ca 65 000 USD. Kostnaden för ett års cancerbehandling med Keytruda uppgår till cirka 130 000 USD. Vi tror dock att en interleukin-blockerande antikropp som CAN04 kommer i fråga först efter en genotypning av tumörresistensen som visar på interleukin-känslighet.